Mammographic density and breast tissue expression of inflammatory markers, growth factors, and vimentin.

ABSTRACT:

Background

Mammographic density is a known risk factor for breast cancer, but the underlying pathologic characteristics are not well understood. The current analysis investigated the expression of several markers of interest, e.g., inflammation and growth, with mammographic density (MD) in normal and malignant breast tissue specimens from 279 women of the Multiethnic Cohort (MEC).

Methods

Breast cancer cases, recruited from a nested case-control study within the MEC, provided mammograms for density evaluation. Protein expression (COX-2, TNF-α, TGF-β, IGF-1R, IGFBP-2, and vimentin) was assessed by immunohistochemical detection. Linear regression was applied to evaluate the relation between marker expression and percent density and to compute adjusted means with 95% confidence

SUBMITTER: Maskarinec G 

PROVIDER: S-EPMC6267911 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature