Are cytokines (IL-6, CRP and adiponectin) associated with bone mineral density in a young adult birth cohort?

ABSTRACT:

Background

Studies have shown that cytokines play a role in bone remodeling.

Methods

In 1993, all hospital births occurred in Pelotas (Brazil) were identified and a total of 5249 newborns were included in the present cohort. Sub-samples of this cohort were visited during childhood and all members were traced at 11, 15, 18 and 22 years old. At 18 and 22 years the following biomarkers were measured: IL-6, CRP and adiponectin (the last one in a sub-sample) and bone mineral density (BMD-mg/cm²) was evaluated at 22 years. Crude regression analysis as well as adjusted for confounders (birth weight, pregnancy maternal smoking, gestational age, skin color, schooling, income, smoking, alcohol, physical activity, medical diagnosis of asthma, diabetes and hypertension, BMI,

SUBMITTER: Menezes AMB 

PROVIDER: S-EPMC6267914 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature