Assessment of metabolic patterns and new antitumoral treatment in osteosarcoma xenograft models by [¹⁸F]FDG and sodium [¹⁸F]fluoride PET.

ABSTRACT:

Background

Osteosarcoma is the most common malignant bone tumor in children and young adults that produces aberrant osteoid. The aim of this study was to assess the utility of 2-deoxy-2-[18F-] fluoro-D-glucose ([¹⁸F] FDG) and sodium [¹⁸F] Fluoride (Na [¹⁸F] F) PET scans in orthotopic murine models of osteosarcoma to describe the metabolic pattern of the tumors, to detect and diagnose tumors and to evaluate the efficacy of a new treatment based in oncolytic adenoviruses.

Methods

Orthotopic osteosarcoma murine models were created by the injection of 143B and 531MII cell lines. [¹⁸F]FDG and Na [¹⁸F] F PET scans were performed 30 days (143B) and 90 days (531MII) post-injection. The antitumor effect of two doses (10⁷

SUBMITTER: Collantes M 

PROVIDER: S-EPMC6267920 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature