Mitonuclear epistasis, genotype-by-environment interactions, and personalized genomics of complex traits in Drosophila.

ABSTRACT: Mitochondrial function requires the coordinated expression of dozens of gene products from the mitochondrial genome and hundreds from the nuclear genomes. The systems that emerge from these interactions convert the food we eat and the oxygen we breathe into energy for life, while regulating a wide range of other cellular processes. These facts beg the question of whether the gene-by-gene interactions (G x G) that enable mitochondrial function are distinct from the gene-by-environment interactions (G x E) that fuel mitochondrial activity. We examine this question using a Drosophila model of mitonuclear interactions in which experimental combinations of mtDNA and nuclear chromosomes generate pairs of mitonuclear genotypes to test for epistatic interactions (G x G). These mitonuclear genotype

SUBMITTER: Rand DM 

PROVIDER: S-EPMC6268205 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature