Food-related compounds that modulate expression of inducible nitric oxide synthase may act as its inhibitors.

ABSTRACT: Natural compounds commonly found in foods may contribute to protect cells against the deleterious effects of inflammation. These anti-inflammatory properties have been linked to the modulation of transcription factors that control expression of inflammation-related genes, including the inducible nitric oxide synthase (iNOS), rather than a direct inhibitory action on these proteins. In this study, forty two natural dietary compounds, known for their ability to exert an inhibitory effect on the expression of iNOS, have been studied in silico as docking ligands on two available 3D structures for this protein (PDB ID: 3E7G and PDB ID: 1NSI). Natural compounds such as silibinin and cyanidin-3-rutinoside and other flavonoids showed the highest theoretical affinities for iNOS. Docking affinity va

SUBMITTER: Maldonado-Rojas W 

PROVIDER: S-EPMC6268506 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature