A facile synthesis for novel loperamide analogs as potential μ opioid receptor agonists.

ABSTRACT: A facile synthesis for novel loperamide analogs as potential μ opioid receptors is described. The synthetic procedure for compound 5, which contains two 4-phenyl piperidine scaffolds, was optimized, and this compound was synthesized in excellent yield. We also describe a mild and highly efficient protocol for the synthesis of compounds 6 and 7.

SUBMITTER: Bao X 

PROVIDER: S-EPMC6268526 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature