Dataset Information

Efficient preparation of α-ketoacetals.

ABSTRACT: The Weinreb amides 2a,b were prepared from the α,α-dimethoxyacetic acids 1c,d. A number of representative nucleophilic additions (RMgX and RLi) on 2 afforded α-ketoacetals 3a-j in 70-99% yield. These compounds represent a versatile arrangement of functional groups of significant synthetic value, as demonstrated in the synthesis of (±)-salbutamol.

SUBMITTER: Ayala-Mata F

PROVIDER: S-EPMC6268805 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Efficient preparation of α-ketoacetals.

Ayala-Mata Francisco F Barrera-Mendoza Citlalli C Jiménez-Vázquez Hugo A HA Vargas-Díaz Elena E Zepeda L Gerardo LG

Molecules (Basel, Switzerland) 20121122 12

The Weinreb amides 2a,b were prepared from the α,α-dimethoxyacetic acids 1c,d. A number of representative nucleophilic additions (RMgX and RLi) on 2 afforded α-ketoacetals 3a-j in 70-99% yield. These compounds represent a versatile arrangement of functional groups of significant synthetic value, as demonstrated in the synthesis of (±)-salbutamol. ...[more]

PMID: 23174902

Dataset Information

Efficient preparation of α-ketoacetals.

Publications

Efficient preparation of α-ketoacetals.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Efficient preparation of α-ketoacetals.

Publications

Efficient preparation of &#945;-ketoacetals.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Efficient preparation of α-ketoacetals.