High salt intake enhances swim stress-induced PVN vasopressin cell activation and active stress coping.

ABSTRACT:

Purpose

Stress contributes to many psychiatric disorders; however, responsivity to stressors can vary depending on previous or current stress exposure. Relatively innocuous heterotypic (differing in type) stressors can summate to result in exaggerated neuronal and behavioral responses. Here we investigated the ability of prior high dietary sodium chloride (salt) intake, a dehydrating osmotic stressor, to enhance neuronal and behavioral responses of mice to an acute psychogenic swim stress (SS). Further, we evaluated the contribution of the osmo-regulatory stress-related neuropeptide arginine vasopressin (VP) in the hypothalamic paraventricular nucleus (PVN), one of only a few brain regions that synthesize VP. The purpose of this study was to determine the impact of high dietary sal

SUBMITTER: Mitchell NC 

PROVIDER: S-EPMC6269109 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature