The Effects of Antipsychotic Treatment on Presynaptic Dopamine Synthesis Capacity in First-Episode Psychosis: A Positron Emission Tomography Study.

ABSTRACT:

Background

Elevated striatal dopamine synthesis capacity has been implicated in the etiology and antipsychotic response in psychotic illness. The effects of antipsychotic medication on dopamine synthesis capacity are poorly understood, and no prospective studies have examined this question in a solely first-episode psychosis sample. Furthermore, it is unknown whether antipsychotic efficacy is linked to reductions in dopamine synthesis capacity. We conducted a prospective [¹⁸F]-dihydroxyphenyl-L-alanine positron emission tomography study in antipsychotic naïve/free people with first-episode psychosis commencing antipsychotic treatment.

Methods

Dopamine synthesis capacity (indexed as influx rate constant) and clinical symptoms (measured using Positive and Negative S

SUBMITTER: Jauhar S 

PROVIDER: S-EPMC6269123 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature