Associations Between Non-neurological Autoimmune Disorders and Psychosis: A Meta-analysis.

ABSTRACT:

Background

A relationship between non-neurological autoimmune (NNAI) disorders and psychosis has been widely reported but not yet subjected to meta-analysis. We conducted the first meta-analysis examining the association between NNAI disorders and psychosis and investigated the effect of 1) temporality (as determined by study design), 2) psychiatric diagnosis, and 3) specific autoimmune disorders.

Methods

Major databases were searched for articles published until April 2018; 31 studies, comprising data for >25 million individuals, were eligible. Using random-effects models, we examined the overall association between all NNAI disorders and psychosis; rheumatoid arthritis was examined separately given the well-established negative association with psychosis. Stratified analys

SUBMITTER: Cullen AE 

PROVIDER: S-EPMC6269125 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature