Shared and Study-specific Dietary Patterns and Head and Neck Cancer Risk in an International Consortium.

ABSTRACT:

Background

A few papers have considered reproducibility of a posteriori dietary patterns across populations, as well as pattern associations with head and neck cancer risk when multiple populations are available.

Methods

We used individual-level pooled data from seven case-control studies (3844 cases; 6824 controls) participating in the International Head and Neck Cancer Epidemiology consortium. We simultaneously derived shared and study-specific a posteriori patterns with a novel approach called multi-study factor analysis applied to 23 nutrients. We derived odds ratios (ORs) and 95% confidence intervals (CIs) for cancers of the oral cavity and pharynx combined, and larynx, from logistic regression models.

Results

We identified three shared patterns that were reprodu

SUBMITTER: De Vito R 

PROVIDER: S-EPMC6269206 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature