Optimizing diagnostic biomarkers of iron deficiency anemia in community-dwelling Indian women and preschool children.

ABSTRACT: The detection of iron deficiency anemia is challenged by the paucity of diagnostic tests demonstrating high sensitivity and specificity. Using two biomarkers, zinc-protoporphyrin/heme and hepcidin, we established the diagnostic cut-off values for iron deficiency anemia in preschool children and women. We randomly selected non-anemic individuals (n=190; women=90, children=100) and individuals with iron deficiency anemia (n=200; women=100, children=100) from a preexisting cohort of healthy preschool children and their mothers. The diagnostic performance of these biomarkers was estimated by analyzing receiver operating characteristic curves. Diagnostic cut-offs with a high predictive value for iron deficiency anemia were selected. Median zinc-protoporphyrin/heme and hepcidin values in non-ane

SUBMITTER: Kanuri G 

PROVIDER: S-EPMC6269316 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature