Silver/silver chloride nanoparticles inhibit the proliferation of human glioblastoma cells.

ABSTRACT: Glioblastomas (GBM) are aggressive brain tumors with very poor prognosis. While silver nanoparticles represent a potential new strategy for anticancer therapy, the silver/silver chloride nanoparticles (Ag/AgCl-NPs) have microbicidal activity, but had not been tested against tumor cells. Here, we analyzed the effect of biogenically produced Ag/AgCl-NPs (from yeast cultures) on the proliferation of GBM02 glioblastoma cells (and of human astrocytes) by automated, image-based high-content analysis (HCA). We compared the effect of 0.1-5.0 µg mL^-1 Ag/AgCl-NPs with that of 9.7-48.5 µg mL^-1 temozolomide (TMZ, chemotherapy drug currently used to treat glioblastomas), alone or in combination. At higher concentrations, Ag/AgCl-NPs inhibited GBM02 proliferation more effectively t

SUBMITTER: Eugenio M 

PROVIDER: S-EPMC6269367 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature