Striatal dopamine deficits predict reductions in striatal functional connectivity in major depression: a concurrent ¹¹C-raclopride positron emission tomography and functional magnetic resonance imaging investigation.

ABSTRACT: Major depressive disorder (MDD) is characterized by the altered integration of reward histories and reduced responding of the striatum. We have posited that this reduced striatal activation in MDD is due to tonically decreased stimulation of striatal dopamine synapses which results in decremented propagation of information along the cortico-striatal-pallido-thalamic (CSPT) spiral. In the present investigation, we tested predictions of this formulation by conducting concurrent functional magnetic resonance imaging (fMRI) and ¹¹C-raclopride positron emission tomography (PET) in depressed and control (CTL) participants. We scanned 16 depressed and 14 CTL participants with simultaneous fMRI and ¹¹C-raclopride PET. We estimated raclopride binding potential (BP_ND

SUBMITTER: Hamilton JP 

PROVIDER: S-EPMC6269434 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature