Three macrophage subsets are identified in the uterus during early human pregnancy.

ABSTRACT: Macrophages are crucial for a successful pregnancy, and malfunctions of decidual macrophages correlate with adverse pregnancy outcomes, such as spontaneous abortion and preeclampsia. Previously, decidual macrophages were often thought to be a single population. In the present study, we identified three decidual macrophage subsets, CCR2-CD11cLO (CD11c^low, ~80%), CCR2-CD11cHI (CD11c^high, ~5%), and CCR2+CD11cHI (CD11c^high, 10-15%), during the first trimester of human pregnancy by flow cytometry analysis. CCR2-CD11cLO macrophages are widely distributed in the decidua, while CCR2-CD11cHI and CCR2+CD11cHI macrophages are primarily detected close to extravillous trophoblast cells according to immunofluorescence staining. According to RNA sequencing bioinformatics

SUBMITTER: Jiang X 

PROVIDER: S-EPMC6269440 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature