MicroRNA cluster miR199a/214 are differentially expressed in female and male rats following nicotine self-administration.

ABSTRACT: Previous research has established sex differences associated with nicotine intake, however a significant gap in knowledge remains regarding the molecular mechanisms that govern these differences at the transcriptional level. One critical regulator of transcription are microRNAs (miRNAs). miRNAs are a family of non-coding RNAs that regulate an array of important biological functions altered in several disease states, including neuroadaptive changes within the brain associated with drug dependence. We examined the prefrontal cortex (PFC) from male and female Sprague-Dawley rats following self-administration (22 days) of nicotine or yoked saline controls using next generation RNA-Sequencing (RNA-Seq) technology and found an array of miRNAs to be significantly and differentially regulated by n

SUBMITTER: Pittenger ST 

PROVIDER: S-EPMC6269448 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature