Incorporating Breast Anatomy in Computational Phenotyping of Mammographic Parenchymal Patterns for Breast Cancer Risk Estimation.

ABSTRACT: We retrospectively analyzed negative screening digital mammograms from 115 women who developed unilateral breast cancer at least one year later and 460 matched controls. Texture features were estimated in multiple breast regions defined by an anatomically-oriented polar grid, and were weighted by their position and underlying dense versus fatty tissue composition. Elastic net regression with cross-validation was performed and area under the curve (AUC) of the receiver operating characteristic (ROC) was used to evaluate ability to predict breast cancer. We also compared our anatomy-augmented features to current state-of-the-art in which parenchymal texture was assessed without considering breast anatomy and evaluated the added value of the extracted features to breast density, body-mass-ind

SUBMITTER: Gastounioti A 

PROVIDER: S-EPMC6269457 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature