Modified VEGF-A mRNA induces sustained multifaceted microvascular response and accelerates diabetic wound healing.

ABSTRACT: Capable of mediating efficient transfection and protein production without eliciting innate immune responses, chemically modified mRNA holds great potential to produce paracrine factors at a physiologically beneficial level, in a spatiotemporally controlled manner, and with low toxicity. Although highly promising in cardiovascular medicine and wound healing, effects of this emerging therapeutic on the microvasculature and its bioactivity in disease settings remain poorly understood. Here, we longitudinally and comprehensively characterize microvascular responses to AZD8601, a modified mRNA encoding vascular endothelial growth factor A (VEGF-A), in vivo. Using multi-parametric photoacoustic microscopy, we show that intradermal injection of AZD8601 formulated in a biocompatible vehicle resul

SUBMITTER: Sun N 

PROVIDER: S-EPMC6269526 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature