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New spiral γ-lactone enantiomers from the plant endophytic fungus Pestalotiopsis foedan.

ABSTRACT: (-)-(4S, 8S)-Foedanolide (1a) and (+)-(4R, 8R)-foedanolide (1b), a pair of new spiro-γ-lactone enantiomers, were isolated from the fermentation broth of the plant endophytic fungus Pestalotiopsis foedan by HPLC using a chiral column, achieving over 7% ee. Their structures and absolute configurations were determined on the basis of extensive analysis of NMR spectra combined with computational methods via calculation of the electronic circular dichroism (ECD) and optical rotation (OR). Compounds 1a and 1b showed moderate activities against HeLa, A-549, U-251, HepG2 and MCF-7 tumor cell lines.

SUBMITTER: Yang XL

PROVIDER: S-EPMC6269859 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature

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New spiral γ-lactone enantiomers from the plant endophytic fungus Pestalotiopsis foedan.

Yang Xiao-Long XL Li Zhuang-Zhuang ZZ

Molecules (Basel, Switzerland) 20130211 2

(-)-(4S, 8S)-Foedanolide (1a) and (+)-(4R, 8R)-foedanolide (1b), a pair of new spiro-γ-lactone enantiomers, were isolated from the fermentation broth of the plant endophytic fungus Pestalotiopsis foedan by HPLC using a chiral column, achieving over 7% ee. Their structures and absolute configurations were determined on the basis of extensive analysis of NMR spectra combined with computational methods via calculation of the electronic circular dichroism (ECD) and optical rotation (OR). Compounds 1 ...[more]

PMID: 23434873

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