A commonly used Chinese herbal formula, Shu-Jing-Hwo-Shiee-Tang, potentiates anticoagulant activity of warfarin in a rabbit model.

ABSTRACT:

Background

Drug interactions between traditional Chinese herbal medicines and the anticoagulant warfarin may cause patient harm and are, therefore, important in clinical practice. Our experience in daily practice suggests that prothrombin time (PT) is prolonged when warfarin is used in combination with the Chinese herbal formula Shu-Jing-Hwo-Shiee-Tang (SJHST) commonly used by patients with osteoarthritis.

Objective

We conducted animal experiments to confirm the effect of SJHST and warfarin on anticoagulant activity.

Methods

Forty-eight male New Zealand white rabbits were randomized into eight groups of six rabbits. Group A (Control group) was administered normal saline. Group B (Western Medicine group) was administered warfarin 1.5 mg/kg/day. Groups C, D, and E [Trad

SUBMITTER: Yang SH 

PROVIDER: S-EPMC6270155 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature