The clip-segment of the von Willebrand domain 1 of the BMP modulator protein Crossveinless 2 is preformed.

ABSTRACT: Bone Morphogenetic Proteins (BMPs) are secreted protein hormones that act as morphogens and exert essential roles during embryonic development of tissues and organs. Signaling by BMPs occurs via hetero-oligomerization of two types of serine/threonine kinase transmembrane receptors. Due to the small number of available receptors for a large number of BMP ligands ligand-receptor promiscuity presents an evident problem requiring additional regulatory mechanisms for ligand-specific signaling. Such additional regulation is achieved through a plethora of extracellular antagonists, among them members of the Chordin superfamily, that modulate BMP signaling activity by binding. The key-element in Chordin-related antagonists for interacting with BMPs is the von Willebrand type C (VWC) module, which

SUBMITTER: Fiebig JE 

PROVIDER: S-EPMC6270503 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature