Synthesis, anticancer activity and UPLC analysis of the stability of some new benzimidazole-4,7-dione derivatives.

ABSTRACT: In this work, a sensitive analytical method to study the stability of two new series of synthesized heterocyclic compounds, the benzimidazole-4,7-diones 5 and N-oxide benzimidazole-4,7-dione derivatives 6 was established and validated. These derivatives were developed as potential anticancer substances to be activated under hypoxic conditions. At this point we were concerned with establishing their stability in some specific environments for further biological studies. For that, we developed and validated an RP-UPLC method. Next, selected compounds were tested in vitro for possible anticancer activity. Their effect on A549 tumour cell lines under normoxia and hypoxia conditions was determined by a WST-1 test. Four of the examined compounds (compounds 5a-c and 6c) showed very good antiproli

SUBMITTER: Blaszczak-Swiatkiewicz K 

PROVIDER: S-EPMC6271476 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature