Cellular transport mechanisms of cytotoxic metallodrugs: an overview beyond cisplatin.

ABSTRACT: The field of medicinal inorganic chemistry has grown consistently during the past 50 years; however, metal-containing coordination compounds represent only a minor proportion of drugs currently on the market, indicating that research in this area has not yet been thoroughly realized. Although platinum-based drugs as cancer chemotherapeutic agents have been widely studied, exact knowledge of the mechanisms governing their accumulation in cells is still lacking. However, evidence suggests active uptake and efflux mechanisms are involved; this may be involved also in other experimental metal coordination and organometallic compounds with promising antitumor activities in vitro and in vivo, such as ruthenium and gold compounds. Such knowledge would be necessary to elucidate the balance between

SUBMITTER: Spreckelmeyer S 

PROVIDER: S-EPMC6271550 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature