Synthesis of functionalized arylaziridines as potential antimicrobial agents.

ABSTRACT: By using the Suzuki-Miyaura protocol, a simple straightforward synthesis of functionalized 2-arylaziridines has been developed. By means of this synthetic strategy from readily available ortho-, meta- and para-bromophenylaziridines and aryl- or heteroarylboronic acids, new aziridines could be obtained. The cross-coupling reactions occurred without ring opening of the three membered ring. Preliminary results on the antimicrobial activity of the heterosubstituted biaryl compounds have been also included.

SUBMITTER: Giovine A 

PROVIDER: S-EPMC6271868 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature