Anticancer and multidrug resistance-reversal effects of solanidine analogs synthetized from pregnadienolone acetate.

ABSTRACT: A set of solanidine analogs with antiproliferative properties were recently synthetized from pregnadienolone acetate, which occurs in Nature. The aim of the present study was an in vitro characterization of their antiproliferative action and an investigation of their multidrug resistance-reversal activity on cancer cells. Six of the compounds elicited the accumulation of a hypodiploid population of HeLa cells, indicating their apoptosis-inducing character, and another one caused cell cycle arrest at the G2/M phase. The most effective agents inhibited the activity of topoisomerase I, as evidenced by plasmid supercoil relaxation assays. One of the most potent analogs down-regulated the expression of cell-cycle related genes at the mRNA level, including tumor necrosis factor alpha and S-phase

SUBMITTER: Zupko I 

PROVIDER: S-EPMC6271930 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature