Hepatic copper concentrations in 546 dogs (1982-2015).

ABSTRACT:

Background

Copper associated hepatitis (CAH) has been increasingly recognized in dogs, and speculation exists that hereditary defects in copper metabolism have been exacerbated by increased environmental copper exposure. However, no broad epidemiological investigations have been performed to investigate quantitative hepatic copper concentrations ([Cu]_H ) over time in both dogs that are (predisposed breed [PB]), and are not (non-predisposed breed [NPB]), considered at-risk for CAH.

Objectives

To investigate [Cu]_H in dogs and explore temporal, demographic, and histologic associations spanning 34 years.

Animals

546 archived liver specimens.

Methods

Retrospective study. Searches of the Michigan State University Veterinary Diagnostic Laboratory

SUBMITTER: Strickland JM 

PROVIDER: S-EPMC6272033 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature