Babesia gibsoni cytochrome b mutations in canine blood samples submitted to a US veterinary diagnostic laboratory.

ABSTRACT:

Background

Babesiosis caused by Babesia gibsoni is recognized throughout the world and can be difficult to treat. Resistance to atovaquone is associated with mutations in the B. gibsoni mitochondrial genome, specifically the M128 position of cytochrome b (cytb). The prevalence of cytb mutations in North America has not been reported.

Hypothesis/objectives

The objective of our study was to describe the prevalence of cytb M128 mutations in B. gibsoni in canine blood samples submitted to a US veterinary diagnostic laboratory. A secondary objective was to determine whether or not some dogs had wild-type cytb in our initial samples then had M128 mutations detected in follow-up samples.

Animals

One-Hundred seventy-four dogs that tested positive for the presence of B. gibson

SUBMITTER: Birkenheuer AJ 

PROVIDER: S-EPMC6272040 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature