Autoantibodies and scleroderma phenotype define subgroups at high-risk and low-risk for cancer.

ABSTRACT:

Objectives

Recent studies demonstrate autoantibodies are powerful tools to interrogate molecular events linking cancer and the development of autoimmunity in scleroderma. Investigating cancer risk in these biologically relevant subsets may provide an opportunity to develop personalised cancer screening guidelines. In this study, we examined cancer risk in distinct serologic and phenotypic scleroderma subsets and compared estimates with the general population.

Methods

Patients in the Johns Hopkins Scleroderma Center observational cohort were studied. Overall and site-specific cancer incidence was calculated in distinct autoantibody and scleroderma phenotypic subsets, and compared with the Surveillance, Epidemiology and End Results registry, a representative sample of the US p

SUBMITTER: Igusa T 

PROVIDER: S-EPMC6272061 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature