Functionally impaired follicular helper T cells induce regulatory B cells and CD14⁺ human leukocyte antigen-DR^- cell differentiation in non-small cell lung cancer.

ABSTRACT: Non-small cell lung cancer (NSCLC) represents one of the most common and aggressive cancers worldwide, as it typically displays irreversible progression and poor prognosis. Interaction between programmed death 1 (PD-1) and its ligand, PD-L1, plays important roles in tumor immunology. Follicular helper T (Tfh) cells have characteristically high PD-1 expression; thus, in the present study, we investigated the role of circulating Tfh cells and their correlation with disease-free survival after tumor resection in NSCLC. We found significantly higher number of Tfh cells but lower serum interleukin (IL)-21 levels in NSCLC patients, especially in those with advanced stage (III and IV), indicating that the function of Tfh cells to produce IL-21 was impaired. Further analysis showed that the increa

SUBMITTER: Qiu L 

PROVIDER: S-EPMC6272090 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature