Synthesis of peptide nucleic acids containing a crosslinking agent and evaluation of their reactivities.

ABSTRACT: Peptide nucleic acids (PNAs) are structural mimics of nucleic acids that form stable hybrids with DNA and RNA. In addition, PNAs can invade double-stranded DNA. Due to these characteristics, PNAs are widely used as biochemical tools, for example, in antisense/antigene therapy. Interstrand crosslink formation in nucleic acids is one of the strategies for preparing a stable duplex by covalent bond formation. In this study, we have synthesized PNAs incorporating 4-amino-6-oxo-2-vinylpyrimidine (AOVP) as a crosslinking agent and evaluated their reactivities for targeting DNA and RNA.

SUBMITTER: Akisawa T 

PROVIDER: S-EPMC6272193 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature