Soy isoflavones in nutritionally relevant amounts have varied nutrigenomic effects on adipose tissue.

ABSTRACT: Soy consumption has been suggested to afford protection from cardiovascular disease (CVD). Indeed, accumulated albeit controversial evidence suggests that daily consumption of ≥25 g of soy protein with its associated phytochemicals intact can improve lipid profiles in hypercholesterolemic humans. However, the belief that soy foods and supplements positively impact human health has become increasingly controversial among the general public because of the reported estrogenic activities of soy isoflavones. In this study, we investigated the nutrigenomic actions of soy isoflavones (in nutritionally-relevant amounts) with a specific focus on the adipose tissue, due to its pivotal role in cardiometabolism. Young C57BL/6 mice were maintained for eight weeks under two different diet regimes: (1) p

SUBMITTER: Giordano E 

PROVIDER: S-EPMC6272387 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature