Non-Invasive Biomarkers for Duchenne Muscular Dystrophy and Carrier Detection.

ABSTRACT: Non-invasive biological indicators of the absence/presence or progress of the disease that could be used to support diagnosis and to evaluate the effectiveness of treatment are of utmost importance in Duchenne Muscular Dystrophy (DMD). This neuromuscular disorder affects male children, causing weakness and disability, whereas female relatives are at risk of being carriers of the disease. A biomarker with both high sensitivity and specificity for accurate prediction is preferred. Until now creatine kinase (CK) levels have been used for DMD diagnosis but these fail to assess disease progression. Herein we examined the potential applicability of serum levels of matrix metalloproteinase 9 and matrix metalloproteinase 2, tissue inhibitor of metalloproteinases 1, myostatin (GDF-8) and follistati

SUBMITTER: Anaya-Segura MA 

PROVIDER: S-EPMC6272409 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature