Synthesis of novel dihydropyridothienopyrimidin-4,9-dione derivatives.

ABSTRACT: A novel molecular scaffold, dihydropyridothienopyrimidin-4,9-dione, was synthesized from benzylamine or p-methoxybenzylamine in six steps involving successive ring closure to form a fused ring system composed of dihydropyridone, thiophene and pyrimidone. The pharmacological versatility of the dihydropyridothenopyrimidin-4,9-dione scaffold was demonstrated by inhibitory activity against metabotropic glutamate receptor subtype 1 (mGluR1), which shows that the title compounds can serve as an interesting scaffold for the discovery of potential bioactive molecules for the treatment of human diseases.

SUBMITTER: Kim Y 

PROVIDER: S-EPMC6272423 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature