Facile access to unnatural dipeptide-alcohols based on cis-2,5-disubstituted pyrrolidines.

ABSTRACT: Well-defined unnatural dipeptide-alcohols based on a cis-2,5-disubstitued pyrrolidine backbone were synthesized from commercially available starting materials meso-diethyl-2,5-dibromoadipate, (S)-(-)-1-phenylethylamine, and phenylalaninol. The structures of these unnatural dipeptide-alcohols are supported by HRMS, 1H- and 13C-NMR spectroscopy. These unnatural dipeptide-alcohols can act as building blocks for peptidomimetics.

SUBMITTER: Jia YY 

PROVIDER: S-EPMC6272547 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature