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New sesquiterpenoids from Ambrosia artemisiifolia L.

ABSTRACT: A new pseudoguaianolide 1 and two new guaiane-type sesquiterpene glucosides 2 and 3, were isolated from the aerial parts of Ambrosia artemisiifolia L together with two known sesquiterpene dilactones 4 and 5. The new compounds were determined on the basis of spectroscopic and chemical methods to be 3?-acetoxy-4?-hydroxy-1?,7?, 10?,11?H-pseudoguaia-12,8?-olide (1), 1?,7?,9?,10?,13?H-guaia-4(5)-en-12,6?-olide 9-O-?-d-glucoside (2) and 4?-hydroxy-1?,5?,7?,9?H-guaia-10(14),11(13)-dien-12-acid 9-O-?-d-glucoside (3). The isolated compounds were evaluated for cytotoxicity against human promyelocytic leukemia HL-60 cell lines in vitro, but were all inactive.

SUBMITTER: Ding W 

PROVIDER: S-EPMC6272762 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature

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New sesquiterpenoids from Ambrosia artemisiifolia L.

Ding Wenbing W   Huang Rui R   Zhou Zhongshi Z   Li Youzhi Y  

Molecules (Basel, Switzerland) 20150310 3

A new pseudoguaianolide 1 and two new guaiane-type sesquiterpene glucosides 2 and 3, were isolated from the aerial parts of Ambrosia artemisiifolia L together with two known sesquiterpene dilactones 4 and 5. The new compounds were determined on the basis of spectroscopic and chemical methods to be 3β-acetoxy-4β-hydroxy-1α,7α, 10β,11αH-pseudoguaia-12,8β-olide (1), 1β,7β,9β,10β,13αH-guaia-4(5)-en-12,6β-olide 9-O-β-d-glucoside (2) and 4β-hydroxy-1α,5α,7α,9αH-guaia-10(14),11(13)-dien-12-acid 9-O-β-d  ...[more]

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