Organocatalyzed Intramolecular Carbonyl-Ene Reactions.

ABSTRACT: An organocatalyzed intramolecular carbonyl-ene reaction was developed to produce carbocyclic and heterocyclic 5- and 6-membered rings from a citronellal-derived trifluoroketone and a variety of aldehydes. A phosphoramide derivative was found to promote the cyclization of the trifluoroketone, whereas a less acidic phosphoric acid proved to be a superior catalyst for the aldehyde substrates.

SUBMITTER: Dahlmann HA 

PROVIDER: S-EPMC6272844 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature