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New Casbane and Cembrane Diterpenoids from an Okinawan Soft Coral, Lobophytum sp.

ABSTRACT: A new rare casbane-type diterpenoid 1 and two new cembrane diterpenoids 2, 3 were isolated from an Okinawan soft coral, Lobophytum sp., together with four known cembrane diterpenoids 4-7. Their structures were elucidated by extensive analysis of spectroscopic data (1D and 2D NMR, IR, and MS) and a molecular modeling study. The new isolates showed weak anti-bacterial activity, mild cytotoxicity against HCT116 cells, and anti-inflammatory effect in LPS/IFN-?-stimulated RAW 264.7 macrophage cells.

SUBMITTER: Roy PK 

PROVIDER: S-EPMC6273427 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature

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New Casbane and Cembrane Diterpenoids from an Okinawan Soft Coral, Lobophytum sp.

Roy Prodip K PK   Ashimine Runa R   Miyazato Haruna H   Taira Junsei J   Ueda Katsuhiro K  

Molecules (Basel, Switzerland) 20160523 5

A new rare casbane-type diterpenoid 1 and two new cembrane diterpenoids 2, 3 were isolated from an Okinawan soft coral, Lobophytum sp., together with four known cembrane diterpenoids 4-7. Their structures were elucidated by extensive analysis of spectroscopic data (1D and 2D NMR, IR, and MS) and a molecular modeling study. The new isolates showed weak anti-bacterial activity, mild cytotoxicity against HCT116 cells, and anti-inflammatory effect in LPS/IFN-γ-stimulated RAW 264.7 macrophage cells. ...[more]

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