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Hydrazonoyl Chlorides as Precursors for Synthesis of Novel Bis-Pyrrole Derivatives.

ABSTRACT: A convenient synthesis of some novel bis-pyrrole derivatives via hydrazonoyl halides is described. Antimicrobial evaluation of some selected examples of the synthesized products was carried out. The bis-pyrrole derivative having chloro substituents showed good activity against all of the used microbes. The molecular docking of the bis-pyrrole derivatives was performed by the Molecular Operating Environment (MOE) program.

SUBMITTER: Kheder NA

PROVIDER: S-EPMC6273510 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature

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Hydrazonoyl Chlorides as Precursors for Synthesis of Novel Bis-Pyrrole Derivatives.

Kheder Nabila Abdelshafy NA

Molecules (Basel, Switzerland) 20160309 3

A convenient synthesis of some novel bis-pyrrole derivatives via hydrazonoyl halides is described. Antimicrobial evaluation of some selected examples of the synthesized products was carried out. The bis-pyrrole derivative having chloro substituents showed good activity against all of the used microbes. The molecular docking of the bis-pyrrole derivatives was performed by the Molecular Operating Environment (MOE) program. ...[more]

PMID: 27005604

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