Unknown

Dataset Information

0

Terpenoids from the Marine-Derived Fungus Aspergillus fumigatus YK-7.

ABSTRACT: Two new ?-bergamotane sesquiterpenoids, E-?-trans-5,8,11-trihydroxybergamot-9-ene (1) and ?-trans-2?,5,15-trihydroxybergamot-10-ene (2), were isolated from the marine-derived fungus Aspergillus fumigatus YK-7, along with three known terpenoids 3-5. Their structures were determined by spectroscopic methods (1D and 2D NMR, HR-ESI-MS). Antiproliferative effects on human leukemic monocyte lymphoma U937 and human prostate cancer PC-3 cell lines were measured in vitro. Compound 4 exhibited potent activity against the U937 cell line with an IC50 value of 4.2 ?M.

SUBMITTER: Wang Y 

PROVIDER: S-EPMC6273775 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Terpenoids from the Marine-Derived Fungus Aspergillus fumigatus YK-7.

Wang Yu Y   Li Da-Hong DH   Li Zhan-Lin ZL   Sun Yan-Jun YJ   Hua Hui-Ming HM   Liu Tao T   Bai Jiao J  

Molecules (Basel, Switzerland) 20151228 1

Two new β-bergamotane sesquiterpenoids, E-β-trans-5,8,11-trihydroxybergamot-9-ene (1) and β-trans-2β,5,15-trihydroxybergamot-10-ene (2), were isolated from the marine-derived fungus Aspergillus fumigatus YK-7, along with three known terpenoids 3-5. Their structures were determined by spectroscopic methods (1D and 2D NMR, HR-ESI-MS). Antiproliferative effects on human leukemic monocyte lymphoma U937 and human prostate cancer PC-3 cell lines were measured in vitro. Compound 4 exhibited potent acti  ...[more]

Similar Datasets

Unknown Genome-Inspired Chemical Exploration of Marine Fungus Aspergillus fumigatus MF071.
| S-EPMC7401266 | biostudies-literature
Unknown Fumigaclavine C from a marine-derived fungus Aspergillus fumigatus induces apoptosis in MCF-7 breast cancer cells.
| S-EPMC3877903 | biostudies-literature
Unknown Seven new Drimane-Type Sesquiterpenoids from a Marine-Derived Fungus Paraconiothyrium sporulosum YK-03.
| S-EPMC6539489 | biostudies-literature
Unknown Methylthio-aspochalasins from a marine-derived fungus Aspergillus sp.
| S-EPMC4210888 | biostudies-other
Unknown Lumazine peptides from the marine-derived fungus Aspergillus terreus.
| S-EPMC4377984 | biostudies-literature
Unknown Sortase A-Inhibitory Metabolites from a Marine-Derived Fungus Aspergillus sp.
| S-EPMC7401278 | biostudies-literature
Unknown Chemical Constituents of the Marine-Derived Fungus Aspergillus sp. SCS-KFD66.
| S-EPMC6316597 | biostudies-literature
Unknown Territrem and butyrolactone derivatives from a marine-derived fungus Aspergillus terreus.
| S-EPMC4278221 | biostudies-literature
Unknown Biologically Active Metabolites from the Marine Sediment-Derived Fungus Aspergillus flocculosus.
| S-EPMC6835654 | biostudies-literature
Unknown New Diketopiperazines from a Marine-Derived Fungus Strain Aspergillus versicolor MF180151.
| S-EPMC6562876 | biostudies-literature