DNA Three Way Junction Core Decorated with Amino Acids-Like Residues-Synthesis and Characterization.

ABSTRACT: Construction and physico-chemical behavior of DNA three way junction (3WJ) functionalized by protein-like residues (imidazole, alcohol and carboxylic acid) at unpaired positions at the core is described. One 5'-C(S)-propargyl-thymidine nucleotide was specifically incorporated on each strand to react through a post synthetic CuACC reaction with either protected imidazolyl-, hydroxyl- or carboxyl-azide. Structural impacts of 5'-C(S)-functionalization were investigated to evaluate how 3WJ flexibility/stability is affected.

SUBMITTER: Addamiano C 

PROVIDER: S-EPMC6274049 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature