Could a Proto-Ribosome Emerge Spontaneously in the Prebiotic World?

ABSTRACT: An indispensable prerequisite for establishing a scenario of life emerging by natural processes is the requirement that the first simple proto-molecules could have had a realistic probability of self-assembly from random molecular polymers in the prebiotic world. The vestige of the proto-ribosome, which is believed to be still embedded in the contemporary ribosome, is used to assess the feasibility of such spontaneous emergence. Three concentric structural elements of different magnitudes, having a dimeric nature derived from the symmetrical region of the ribosomal large subunit, were suggested to constitute the vestige of the proto-ribosome. It is assumed to have materialized spontaneously in the prebiotic world, catalyzing non-coded peptide bond formation and simple elongation. Probabili

SUBMITTER: Agmon IC 

PROVIDER: S-EPMC6274258 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature