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Two New Secondary Metabolites from the Endophytic Fungus Endomelanconiopsis endophytica.

ABSTRACT: Two new secondary metabolites, endomeketals A-B (1-2), a new natural product (3), and a known compound (4) were isolated from the ethyl acetate extract of the endophytic fungus Endomelanconiopsis endophytica A326 derived from Ficus hirta. Their structures were determined on the basis of extensive spectroscopic analysis. All compounds were evaluated for their cytotoxic activities against SF-268, MCF-7, NCI-H460, and HepG-2 tumor cell lines. However, no compound showed cytotoxic activity against these human tumor cell lines.

SUBMITTER: Sun ZH 

PROVIDER: S-EPMC6274285 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature

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Two New Secondary Metabolites from the Endophytic Fungus Endomelanconiopsis endophytica.

Sun Zhang-Hua ZH   Li Hao-Hua HH   Liang Fa-Liang FL   Chen Yu-Chan YC   Liu Hong-Xin HX   Li Sai-Ni SN   Tan Guo-Hui GH   Zhang Wei-Min WM  

Molecules (Basel, Switzerland) 20160720 7

Two new secondary metabolites, endomeketals A-B (1-2), a new natural product (3), and a known compound (4) were isolated from the ethyl acetate extract of the endophytic fungus Endomelanconiopsis endophytica A326 derived from Ficus hirta. Their structures were determined on the basis of extensive spectroscopic analysis. All compounds were evaluated for their cytotoxic activities against SF-268, MCF-7, NCI-H460, and HepG-2 tumor cell lines. However, no compound showed cytotoxic activity against t  ...[more]

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