Acetaminophen Induced Hepatotoxicity in Wistar Rats--A Proteomic Approach.

ABSTRACT: Understanding the mechanism of chemical toxicity, which is essential for cross-species and dose extrapolations, is a major challenge for toxicologists. Standard mechanistic studies in animals for examining the toxic and pathological changes associated with the chemical exposure have often been limited to the single end point or pathways. Toxicoproteomics represents a potential aid to the toxicologist to understand the multiple pathways involved in the mechanism of toxicity and also determine the biomarkers that are possible to predictive the toxicological response. We performed an acute toxicity study in Wistar rats with the prototype liver toxin; the acetaminophen (APAP) effects on protein profiles in the liver and its correlation with the plasma biochemical markers for liver injury were

SUBMITTER: Ilavenil S 

PROVIDER: S-EPMC6274323 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature