The p53-signaling pathway and colorectal cancer: Interactions between downstream p53 target genes and miRNAs.

ABSTRACT:

Introduction

We examined expression of genes in the p53-signaling pathway. We determine if genes that have significantly different expression in carcinoma tissue compared to normal mucosa also have significantly differentially expressed miRNAs. We utilize a sample of 217 CRC cases.

Methods

We focused on fold change (FC) > 1.50 or <0.67 for genes and miRNAs, that were statistically significant after adjustment for multiple comparisons. We evaluated the linear association between the differential expression of miRNA and mRNA. miRNA:mRNA seed-region matches also were determined.

Results

Eleven dysregulated genes were associated with 37 dysregulated miRNAs; all were down-stream from the TP53 gene. MiR-150-5p (HR = 0.82) and miR-196b-5p (HR 0.73) significantly reduced the

SUBMITTER: Slattery ML 

PROVIDER: S-EPMC6274615 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature