Association of newborn screening metabolites with risk of wheezing in childhood.

ABSTRACT:

Background

There are critical gaps in our understanding of the temporal relationships between metabolites and subsequent asthma development. This is the first study to examine metabolites from newborn screening in the etiology of early childhood wheezing.

Methods

One thousand nine hundred and fifty one infants enrolled between 2012 and 2014 from pediatric practices located in Middle Tennessee in the population-based birth cohort study, the Infant Susceptibility to Pulmonary Infections and Asthma Following RSV Exposure Study (INSPIRE), were linked with metabolite data from the Tennessee Newborn Screening Program. The association between the levels of 37 metabolites and the number of wheezing episodes in the past 12 months was assessed at 1, 2, and 3 years of life.

Results<

SUBMITTER: Donovan BM 

PROVIDER: S-EPMC6274622 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature