Beclin-1-Dependent Autophagy Protects the Heart During Sepsis.

ABSTRACT:

Background

Cardiac dysfunction is a major component of sepsis-induced multiorgan failure in critical care units. Changes in cardiac autophagy and its role during sepsis pathogenesis have not been clearly defined. Targeted autophagy-based therapeutic approaches for sepsis are not yet developed.

Methods

Beclin-1-dependent autophagy in the heart during sepsis and the potential therapeutic benefit of targeting this pathway were investigated in a mouse model of lipopolysaccharide (LPS)-induced sepsis.

Results

LPS induced a dose-dependent increase in autophagy at low doses, followed by a decline that was in conjunction with mammalian target of rapamycin activation at high doses. Cardiac-specific overexpression of Beclin-1 promoted autophagy, suppressed mammalian target of r

SUBMITTER: Sun Y 

PROVIDER: S-EPMC6274625 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature