Calcium Signaling in Vertebrate Development and Its Role in Disease.

ABSTRACT: Accumulating evidence over the past three decades suggests that altered calcium signaling during development may be a major driving force for adult pathophysiological events. Well over a hundred human genes encode proteins that are specifically dedicated to calcium homeostasis and calcium signaling, and the majority of these are expressed during embryonic development. Recent advances in molecular techniques have identified impaired calcium signaling during development due to either mutations or dysregulation of these proteins. This impaired signaling has been implicated in various human diseases ranging from cardiac malformations to epilepsy. Although the molecular basis of these and other diseases have been well studied in adult systems, the potential developmental origins of such disease

SUBMITTER: Paudel S 

PROVIDER: S-EPMC6274931 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature