Arachidonic Acid Metabolites in Cardiovascular and Metabolic Diseases.

ABSTRACT: Lipid and immune pathways are crucial in the pathophysiology of metabolic and cardiovascular disease. Arachidonic acid (AA) and its derivatives link nutrient metabolism to immunity and inflammation, thus holding a key role in the emergence and progression of frequent diseases such as obesity, diabetes, non-alcoholic fatty liver disease, and cardiovascular disease. We herein present a synopsis of AA metabolism in human health, tissue homeostasis, and immunity, and explore the role of the AA metabolome in diverse pathophysiological conditions and diseases.

SUBMITTER: Sonnweber T 

PROVIDER: S-EPMC6274989 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature