Preclinical progenitor cell therapy in traumatic brain injury: a meta-analysis.

ABSTRACT:

Background

No treatment is available to reverse injury associated with traumatic brain injury (TBI). Progenitor cell therapies show promise in both preclinical and clinical studies. We conducted a meta-analysis of preclinical studies using progenitor cells to treat TBI.

Methods

EMBASE, MEDLINE, Cochrane Review, Biosis, and Google Scholar were searched for articles using prespecified search strategies. Studies meeting inclusion criteria underwent data extraction. Analysis was performed using Review Manager 5.3 according to a fixed-effects model, and all studies underwent quality scoring.

Results

Of 430 abstracts identified, 38 met inclusion criteria and underwent analysis. Average quality score was 4.32 of 8 possible points. No study achieved a perfect score. Lesion vo

SUBMITTER: Jackson ML 

PROVIDER: S-EPMC6275127 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature