Gut microbiota metabolites, amino acid metabolites and improvements in insulin sensitivity and glucose metabolism: the POUNDS Lost trial.

ABSTRACT:

Objective

Alterations in gut microbiota have been linked to host insulin resistance, diabetes and impaired amino acid metabolism. We investigated whether changes in gut microbiota-dependent metabolite of trimethylamine N-oxide (TMAO) and its nutrient precursors (choline and L-carnitine) were associated with improvements in glucose metabolism and diabetes-related amino acids in a weight-loss diet intervention.

Design

We included 504 overweight and obese adults who were randomly assigned to one of four energy-reduced diets varying in macronutrient intake. The 6-month changes (Δ) in TMAO, choline and L-carnitine levels after the intervention were calculated.

Results

Greater decreases in choline and L-carnitine were significantly (p<0.05) associated with greater improveme

SUBMITTER: Heianza Y 

PROVIDER: S-EPMC6275143 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature